BGC > Produktsuche > LY 411575 | 209984-57-6

Molecular Formula: C26H23F2N3O4
Molecular Weight: 479.481
WGKGermany: 3
HS Code: 29337900

Description:
LY-411575, also known as LSN-411575, is a potent, cell-permeable γ-secretase inhibitor (IC50 = 0.078 nM/0.082 nM in membrane-assay/in cell-basedγ-secretase assays) and also inhibits Notch clevage (IC50 = 0.39 nM).

• Molecular Weight:479.48
• Purity:>98%

Molecular Formula:
C26H23F2N3O4
Canonical SMILES:
CC(C(=O)NC1C2=CC=CC=C2C3=CC=CC=C3N(C1=O)C)NC(=O)C(C4=CC(=CC(=C4)F)F)O
InChI:
1S/C26H23F2N3O4/c1-14(29-25(34)23(32)15-11-16(27)13-17(28)12-15)24(33)30-22-20-9-4-3-7-18(20)19-8-5-6-10-21(19)31(2)26(22)35/h3-14,22-23,32H,1-2H3,(H,29,34)(H,30,33)/t14-,22-,23-/m0/s1
InChIKey:
ULSSJYNJIZWPSB-CVRXJBIPSA-N
Solubility:
Soluble to 95 mg/mL in DMSO
Appearance:
White to off-white solid
Storage: Store in a cool and dry place and at 0 - 4℃ for short term (days to weeks) or -38℃ for long term (months to years).
Synonyms:
LY 411575; LY-411575; LY411575; LSN-411575; LSN 411575; LSN411575. (2S)-2-[[(2S)-2-(3,5-difluorophenyl)-2-hydroxyacetyl]amino]-N-[(7S)-5-methyl-6-oxo-7H-benzo[d][1]benzazepin-7-yl]propanamide; LY 411,575; LY 411575; LY 450139; LY-411,575; LY-411575; LY411,575; LY411575; LY450139; N2-((2S)-2-(3,5-difluorophenyl)-2-hydroxyethanoyl)-N1-((7S)-5-methyl-6-oxo-6,7-dihydro-5H-dibenzo(b,d)azepin-7-yl)-L-alaninamide; N2-(2-(3,5-difluorophenyl)-2-hydroxyethanoyl)-N1-(5-methyl-6-oxo-6,7-dihydro-5H-dibenzo(b,d)azepin-7-yl)alaninamide; Semagacestat; 209984-57-6